THREE-DIMENSIONAL MODELS AS A NEW FRONTIER FOR STUDYING THE ROLE OF PROTEOGLYCANS IN THE NORMAL AND MALIGNANT BREAST MICROENVIRONMENT

Three-Dimensional Models as a New Frontier for Studying the Role of Proteoglycans in the Normal and Malignant Breast Microenvironment

The extracellular matrix (ECM) provides cues to direct mammogenesis, tumourigenesis and metastatic processes.Over the past several decades, two-dimensional (2D) culture models have been invaluable in furthering our understanding of the tumor microenvironment (TME), however, they still do not accurately emulate the associated biological complexities

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Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

Abstract Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth.Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment.Despite Ambient Lighting attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pru

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Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints

Survival rates for metastatic lung cancer, including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), are poor with 5-year survivals of less than 5%.The immune system has an intricate and complex relationship with tumorigenesis; a groundswell of research on the immune system is leading to greater understanding of how cancer pro

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Susceptibility of Bread Wheat Cultivars to Wheat Gall Nematode and A Study Some of the Gene Action of Infection Percentage

Sandals Screening of 15 wheat cultivars against wheat gall nematode Anguina tirtici con firmed that sabebage cultivar immune to this pest ,while different levels of Susceptibility was recorded on the other 14 cultivates.F1 crosses were showed significantly positive ,heterosis for its Nematodes sensitivity and no any one negative.Combining ability a

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Discrepancies among Scopus and Web of Science, coverage of funding information in medical journal articles: a follow-up study

Objective: This follow-up study aims to determine if and how the coverage of funding information in Web of Science Core Collection (WoS) and Scopus changed from Fan Shop - Team Canada - Jerseys 2015 to 2021.Methods: The number of all funded articles published in 2021 was identified in WoS and Scopus bibliographic databases using bibliometric analys

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